Myristoylation of cgmp-dependent protein kinase dictates isoform specificity for serotonin transporter regulation*

HIGHLIGHTS

• who: Yuan-Wei Zhang from the Yuan-Wei Zhang and Gary Rudnick, From the Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut, By transporting serotonin (5-HT) into neurons and other cells, serotonin transporter (SERT) modulates the action of, HT at cell surface receptorsSERT itself is modulated by several processes, including the cGMP signaling pathway. Activation of SERT by cGMP requires the cGMP-dependent protein kinase (PKG). Here we show that in HeLa cells lacking endogenous PKG, expression of PKGI␣ or PKGI␤ was required for, bromoguanosine-3ⴕ, ⴕ-cyclic monophosphate (8-Br-cGMP) to stimulate . . .
  

   

  

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