N-terminal domain of tyrosyl-dna phosphodiesterase i regulates topoisomerase i-induced toxicity in cells

HIGHLIGHTS

• who: Evan J. Brettrager from the DepartmentUniversity of have published the Article: N-terminal domain of tyrosyl-DNA phosphodiesterase I regulates topoisomerase I-induced toxicity in cells, in the Journal: Scientific Reports Scientific Reports

SUMMARY

N‑terminal truncated Tdp1 mutants do not generate a TOP1‑dependent toxicity. The yeast primary nls-sequence contains amino_acid (AA) 8-17, while a functional secondary nls, AA 232-253, is located in catalytic domain (Fig 1a). Conversely, expression of the analogous N-terminal truncated mutant proteins displays a similar viability as the truncated wild-type Tdp1 (Fig . . .

 



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