N1-methyl-pseudouridine is incorporated with higher fidelity than pseudouridine in synthetic rnas

HIGHLIGHTS

• who: Tien-Hao Chen from the (UNIVERSITY) have published the paper: N1-methyl-pseudouridine is incorporated with higher fidelity than pseudouridine in synthetic RNAs, in the Journal: Scientific Reports Scientific Reports
• what: Based on the data from multiple templates and reaction conditions, the authors demonstrate that both ψ and m1ψ have a higher propensity to mis-pair with dT in the template DNA during in_vitro transcription.
• future: Future studies to elucidate the role of residues outside of the active_site on fidelity of modified nucleotide incorporation will be instrumental in designing high-fidelity in_vitro transcription . . .
  

   

  

  If you want to have access to all the content you need to log in!

  Thanks :)

  Username or Email

  Password

  Remember me

  Lost your password?

  If you don't have an account, you can create one here.