HIGHLIGHTS
- who: Mengyun Peng from the SchoolMedical University have published the article: Nanodrug rescues liver fibrosis via synergistic therapy with H2O2 depletion and Saikosaponin b1 sustained release, in the Journal: (JOURNAL) of 13/06/2022
- what: The authors explored clinical specimens obtained from cirrhosis patients and a mouse model of to demonstrate upregulated HIF-1u03b1 decreased CAT activity and H2O2 accumulation in fibrotic regions. The authors designed a with biodegradable poly (lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) loading a hydrophobic antifibrotic drug Ssb1 (Fig 3a)39 40. This study showed that hypoxia induces increased TGFu03b21 . . .
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