Nanopore sequencing for detection and characterization of phosphorothioate modifications in native dna sequences

HIGHLIGHTS

  • who: ufeffIntawatufeff ufeffNookaewufeff from the Department of Biomedical Informatics, University of Arkansas for Medical Sciences, Little Rock, AR, United States have published the paper: Nanopore Sequencing for Detection and Characterization of Phosphorothioate Modifications in Native DNA Sequences, in the Journal: (JOURNAL)
  • what: The authors report herein the detection of PT modification by epitranscriptional landscape inferring from glitches of ONT signals (ELIGOS) using synthetic PT modifications and native DNA from S. enterica containing naturally occurring PT modifications in wild-type, dndB knockout (u2206dndB) mutant (known to increase PT modifications), and dndC knockout (u2206dndC) mutant (known to . . .

     

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