Nanopore sequencing of clonal igh rearrangements in cell-free dna as a biomarker for acute lymphoblastic leukemia

HIGHLIGHTS

• who: Shilpa Sampathi et al. from the Harvard Medical School, United States Tabriz University of Medical Sciences have published the paper: Nanopore sequencing of clonal IGH rearrangements in cell-free DNA as a biomarker for acute lymphoblastic leukemia, in the Journal: (JOURNAL)
• what: The authors focused on analyses of the unique patient-specific variable region rearrangements (IGHV) and tracked these clones throughout the treatment. The study demonstrates the utility of MinION-based Nanopore sequencing of IGH rearrangement from the cfDNA to quickly visualize B-ALL clonal heterogeneity and track clonal response to treatment from patient . . .
  

   

  

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