HIGHLIGHTS
- who: Shuang Peng and collaborators from the Institute of Pharmacology, University of Bern, Bern, Switzerland, State Key Laboratory of Pharmaceutical have published the research work: Nascent RHOH acts as a molecular brake on actomyosin-mediated effector functions of inflammatory neutrophils, in the Journal: (JOURNAL) of February/20,/2022
- what: Strikingly the authors show here that RHOH although being constitutively GTP-bound limits neutrophil degranulation and the formation of neutrophil extracellular traps (NETs). The authors demonstrate that neutrophils display increased RHOH expression after exposure to inflammatory stimuli and concomitant decreased ability in degranulation and NET formation . . .
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