Nat10 regulates neutrophil pyroptosis in sepsis via acetylating ulk1 rna and activating sting pathway

HIGHLIGHTS

• who: Hao Zhang from the Zhongshan Hospital Fudan University, Shanghai, China have published the research work: NAT10 regulates neutrophil pyroptosis in sepsis via acetylating ULK1 RNA and activating STING pathway, in the Journal: (JOURNAL)
• what: The authors identified ULK1 as the target of NAT10 whose stability can be augmented by NAT10-dependent ac4C and the expression enhanced. This study described the negative regulation of NAT10 on neutrophil pyroptosis and its protective role in sepsis.
• how: Neutrophils were harvested from peripheral blood spleens and BALF. f Activation of and IRF3 in neutrophils were detected . . .
  

   

  

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