HIGHLIGHTS
- who: Dauren Biyashev from the (UNIVERSITY) have published the paper: Natural Angiogenesis Inhibitor Signals through Erk5 Activation of Peroxisome Proliferator-activated Receptor γ (PPARγ)*, in the Journal: (JOURNAL) of April/30,/2010
- how: Erk5 Was Essential for the Angiogenesis Blockade by PEDF- To determine if Erk5 was essential for PEDF anti-angiogenic signaling the authors utilized the dominant-negative (DN-MEK5) and constitutively active (CA-MEK5) mutants of the Erk5-activating kinase MEK5. The resultant cells were tested in the endothelial cell chemotaxis assay.
SUMMARY
Whereas its catalytic domain is homologous to . . .
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