HIGHLIGHTS
SUMMARY
Cytokines then drive the following processes: (i) the direct lysing of cancer cells or the capture of dead cancer cells; (ii) antigen processing performed by phagocytose cancer cells; (iii) the activation of T_cells mediated adaptive anti-tumor immune_responses; and_(iv) the release of cytoplasmic granules containing perforin and granzymes, which directly kill cancer cells and so on. Some tumors induce T regulatory cells to repress tumor-distinct T_cell reactions. Some cancers also induce the expression of PD-L1, thereby exhausting T_cells through interaction with PD-1. TIGIT and CD96 TIGIT is an immunosuppressive receptor . . .
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