HIGHLIGHTS
- who: EGFR-TKI resistance and collaborators from the University of Texas MD Anderson Cancer Center, United States have published the Article: Natural product manoalide promotes EGFR-TKI sensitivity of lung cancer cells by KRAS-ERK pathway and mitochondrial Ca overload-induced ferroptosis, in the Journal: (JOURNAL)
- what: The authors investigated the effect of MA on the viability of lung cancer cells and organoids and found that MA promoted the sensitivity of KRAS-mutated lung cancer cells to osimertinib through ROS inhibition of the RAS-ERK pathway and increased the sensitivity of osimertinib-resistant lung cancer . . .
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