Natural product preferentially targets redox and metabolic adaptations and aberrantly active stat3 to inhibit breast tumor growth in vivo

HIGHLIGHTS

• who: Yinsong Zhu from the (UNIVERSITY) have published the article: Natural product preferentially targets redox and metabolic adaptations and aberrantly active STAT3 to inhibit breast tumor growth in vivo, in the Journal: (JOURNAL) of 23/Nov/2022
• what: The authors show that both NADPH and NADP+ levels in the TNBC, MDA-MB231 and MDA-MB-468 cells are significantly higher than in the normal human breast epithelial, MCF-10A cells (Fig 3Ai). The authors report the antitumor activity of R001 against human TNBC in_vitro and in_vivo, consistent with the previous report of the Cell Death . . .
  

   

  

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