HIGHLIGHTS
- who: Catherine L. Tooke from the Catherine LTooke1, Philip Hinchliffe1, Robert A. Bonomo3, , Christopher J. Schofield6, Adrian J. Mulholland2, and James Spencer1, * From the School of Cellular and Molecular Medicine, Biomedical Sciences Building, and Centre for Computational Chemistry, School of Chemistry, University of Bristol, Bristol, United Kingdom have published the research: Natural variants modify Klebsiella pneumoniae carbapenemase (KPC) acyl-enzyme conformational dynamics to extend antibiotic resistance, in the Journal: (JOURNAL) of October/18,/2020
- what: The authors compare ESOC hydrolysis by the parent enzyme KPC-2 and its clinically observed double variant (P104R/V240G) KPC . . .
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