Ncs-1 inhibits insulin-stimulated glut4 translocation in 3t3l1 adipocytes through a phosphatidylinositol 4-kinase-dependent pathway*

HIGHLIGHTS

• who: Silvia Mora from the (UNIVERSITY) have published the Article: NCS-1 Inhibits Insulin-stimulated GLUT4 Translocation in 3T3L1 Adipocytes through a Phosphatidylinositol 4-Kinase-dependent Pathway*, in the Journal: (JOURNAL) of April/16,/2002
• what: The authors demonstrate that overexpression of NCS-1 in 3T3L1 adipocytes inhibits GLUT4 translocation through its interaction with PI 4-kinase ␤.

SUMMARY

The inhibitory action of NCS-1 was independent of calcium sequestration since neither treatment with ionomycin nor endothelin-1, both of which elevated the intracellular calcium concentration, restored insulin-stimulated GLUT4 translocation. Overexpression . . .

 



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