Ncs1 overexpression restored mitochondrial activity and behavioral alterations in a zebrafish model of wolfram syndrome

HIGHLIGHTS

  • who: Lucie Crouzier and collaborators from the France France have published the article: NCS1 overexpression restored mitochondrial activity and behavioral alterations in a zebrafish model of Wolfram syndrome, in the Journal: (JOURNAL) of 27/Dec/2022
  • what: The aim of this study was to characterize a zebrafish model of WS, with non-functional Wfs1a nor Wfs1b proteins, and to challenge the hypothesis that an overexpression of Ncs1 in_vivo would restore most of the observed behavioral and cellular alterations shown by the mutant line. While this study is focused on Wolfram syndrome zebrafish model larvae and . . .

     

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