Ndr2 kinase contributes to cell invasion and cytokinesis defects induced by the inactivation of rassf1a tumor-suppressor gene in lung cancer cells

HIGHLIGHTS

• who: Maureen Keller from the (UNIVERSITY) have published the research: NDR2 kinase contributes to cell invasion and cytokinesis defects induced by the inactivation of RASSF1A tumor-suppressor gene in lung cancer cells, in the Journal: (JOURNAL)
• what: The authors demonstrate here that depletion of the YAP-kinases NDR1/2 reverts migration and metastatic properties upon RASSF1A loss in HBEC. The authors show that interacts directly with (which contains the phosphorylation consensus motif HXRXXS/T) leading to phosphorylation. The authors provide evidence for a NDR2/GEF-H1 interaction, leading to GEF-H1 Ser885 phosphorylation/inactivation, followed . . .
  

   

  

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