HIGHLIGHTS
SUMMARY
Among lung cancers, lung adenocarcinoma (LUAD) is the most common subtype of non-small-cell lung cancer (NSCLC), accounting for 50% of all NSCLC cases (Denisenko et_al, 2018; Peng et_al, 2018). Caspase is well known as an essential component of apoptosis that can modulate multiple pathways (Wong, 2011; Maes et_al, 2017). Only when caspase activity is inhibited can some death-related receptors, such as tumor necrosis factor receptors, be activated, resulting in the activation of downstream RIPK1, RIPK3, and MLKL and formation of necrosomes, eventually mediating necroptosis (Nunes et_al, 2014; Cao et_al, 2018; Yuan . . .
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