HIGHLIGHTS
- who: Jianqiu Zou from the Augusta, GA, USA Medical University have published the research work: Neddylation is required for perinatal cardiac development through stimulation of metabolic maturation, in the Journal: (JOURNAL) of January/31,/2023
- what: The authors report the indispensable role of cardiac maturation. The authors show that HIF1a is putative target and that inhibition of accumulates HIF1a and impairs fatty acid utilization and bioenergetics cardiomyocytes. Using strategies to conditionally delete the gene encoding NAE1 in mice, the authors demonstrate that neddylation is necessary for proper control of CM metabolic transition and for normal . . .
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