Negative feed-forward control of tumor necrosis factor (tnf) by tristetraprolin (zfp36) is limited by the mitogen-activated protein kinase phosphatase, dual-specificity phosphatase 1 (dusp1)

HIGHLIGHTS

• who: Suharsh Shah from the Suharsh Shah, Mahmoud MMostafa, Andrew McWhae, Suzanne L. Traves, and Robert Newton, From the Airways Inflammation Research Group, Snyder Institute for Chronic Diseases, University of Calgary, Calgary, Alberta T N , Canada Background: , negatively regulates AU-rich element-containing mRNAs. Results: , silencing increases , expression and enhances negative feed-forward control of TNF. Conclusions: MAPK inhibition initially attenuates TNF mRNA, but reduced feed-forward control subsequently produces an increase. Significance: Understanding such networks is essential to develop novel anti-inflammatory therapies or understand TNF repression by glucocorticoids, which may not require , or , expression. TNF . . .
  

   

  

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