Neonatal hepatic myeloid progenitors expand and propagate liver injury in mice

HIGHLIGHTS

• who: Anas Alkhani and collaborators from the Department of Surgery, University of California, San Francisco, CA, USA have published the article: Neonatal Hepatic Myeloid Progenitors Expand and Propagate Liver Injury in Mice, in the Journal: (JOURNAL)
• what: Using this model, the authors compared HSPCs and mature myeloid populations from the liver and BM in the setting of homeostasis and PLI. The study demonstrates that myeloid progenitors increase during PLI and that their depletion improves disease outcome.
• future: The authors expect that the short duration of myeloablation the authors used in neonatal mice would . . .
  

   

  

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