Neonatal inflammation increases hippocampal kcc2 expression through methylation-mediated tgf-β1 downregulation leading to impaired hippocampal cognitive function and synaptic plasticity in adult mice

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SUMMARY

Western blot analysis in Fig 6C further showed that TGF-β1 protein greatly enhanced by TGF-β1 vector in control mice and LPS mice when compared with control vector-treated control mice (P=0.0002) and LPS mice (P=0.0003), respectively. Using patch-clamp techniques, the authors found that there was a marked increase in the amplitude but not frequency of GABAergic mIPSCs in adult LPS mice, which suggests that enhanced GABAergic synaptic transmission in adult LPS mice is caused by changes in postsynaptic function. Based these results, it is believed that the . . .

 



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