Neonatal net-inhibitory factor improves survival in the cecal ligation and puncture model of polymicrobial by inhibiting neutrophil extracellular traps

HIGHLIGHTS

  • who: Claudia V. de Araujo and collaborators from the University of Calgary, Canada have published the article: Neonatal NET-Inhibitory Factor improves survival in the cecal ligation and puncture model of polymicrobial by inhibiting neutrophil extracellular traps, in the Journal: (JOURNAL)
  • what: The authors report that treatment with nNIF in a clinically relevant dosing regimen initiated 4 hours after cecal ligation and puncture (CLP), either as monotherapy or as an adjuvant to systemic antibiotic treatment, improves clinical illness severity and survival in the CLP model of experimental polymicrobial sepsis. Considering all the data together, the . . .

     

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