Network hamiltonian models reveal pathways to amyloid fibril formation

HIGHLIGHTS

  • who: Yue Yu from the DepartmentUniversity of USA have published the paper: Network Hamiltonian models reveal pathways to amyloid fibril formation, in the Journal: Scientific Reports Scientific Reports of 15/05/2020
  • how: The modeling framework is based on the notion of aggregation graphs topological representations of protein aggregation states in which each vertex corresponds to a single protein monomer and each edge corresponds to a non-covalent interaction between monomers.
  • future: The kinetic extension of the ERGM framework used here to model time-dependent aggregation events is obtained by adapting a common . . .

     

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