Neural-net-based cell deconvolution from dna methylation reveals tumor microenvironment associated with cancer prognosis

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  • What: The authors also explored the potential application of MEnet to actual diseases by analyzing tumor tissues of intrahepatic cholangiocarcinoma (ICC). Through the analysis of tumor tissues from 72 ICC patients, the authors demonstrate that the prognosis of ICC patients, such as life span and recurrence time, can be estimated by the tumor microenvironment inferred by MEnet. dard phenol-chloroform extraction method and precipitated with ethanol. The authors also demonstrated the efficacy of cell profiling in a large dataset of ICC.
  • Who: Yasumizu Yoshiaki and collaborators from the Department of Experimental Immunology, Immunology Frontier Research . . .

     

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