HIGHLIGHTS
- who: Erik P. Lillehoj from the (UNIVERSITY) have published the article: Neuraminidase 1⠍mediated desialylation of the mucin 1 ectodomain releases a decoy receptor that protects against Pseudomonas aeruginosa lung infection, in the Journal: (JOURNAL) of September/26,/2018
SUMMARY
The MUC1-ED desialylation unmasks both cryptic binding_sites for Pa and a protease recognition site, permitting its proteolytic release as a hyperadhesive decoy receptor for Pa. A flagellindeficient PAK mutant provoked dramatically reduced MUC1-ED shedding compared with the WT strain, and purified flagellin recapitulated the WT effect. NEU1-selective sialidase inhibition protected . . .
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