Neurogenin3 phosphorylation controls reprogramming efficiency of pancreatic ductal organoids into endocrine cells

HIGHLIGHTS

• who: from the (UNIVERSITY) have published the research work: Neurogenin3 phosphorylation controls reprogramming efficiency of pancreatic ductal organoids into endocrine cells, in the Journal: (JOURNAL) of 22/06/2018
• what: The authors focused on gene sets associated with α- and β-cell identity that have been recently identified through single cell analysis of mouse pancreatic islets29. The authors show that preventing Ngn3 phosphorylation at cdk targeted sites results in an almost 4-fold increase in fate reprogramming (Fig 7D).

SUMMARY

Using mouse pancreatic ductal organoids, the authors see that co-expression of Ngn3 . . .

 



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