Neuronal development is promoted by weakened intrinsic antioxidant defences due to epigenetic repression of nrf2

HIGHLIGHTS

• who: Karen F. S. Bell from the Centre for Integrative Physiology, University of Edinburgh, Edinburgh , XD, MRC Centre for Regenerative Medicine, University of Edinburgh have published the article: Neuronal development is promoted by weakened intrinsic antioxidant defences due to epigenetic repression of Nrf2, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS of 13/05/2015
• what: The authors show that early in mouse cortical neuronal development in vitro and in vivo expression of the master-regulator of antioxidant genes transcription factor NF-E2-related-factor-2 (Nrf2) is repressed by epigenetic inactivation of its promoter. The . . .
  

   

  

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