Neuronal genes deregulated in cornelia de lange syndrome respond to removal and re-expression of cohesin

HIGHLIGHTS

• who: Felix D. Weiss from the Institut at The University of have published the research work: Neuronal genes deregulated in Cornelia de Lange Syndrome respond to removal and re-expression of cohesin, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
• what: The authors examine gene_expression in neuronal nuclei isolated from post-mortem cerebral cortex of CdLS patients.
• how: To ask whether the observed rescue of gene_expression reflected adaptation of neurons to reduced cohesin function the authors carried out RNA-seq experiments after prolonged depletion of RAD21-TEV. Sequence data was analysed using the 4 . . .
  

   

  

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