Neuronal sphingosine kinase 2 subcellular localization is altered in alzheimer’s disease brain

HIGHLIGHTS

• who: Gaëlle Dominguez from the (UNIVERSITY) have published the research: Neuronal sphingosine kinase 2 subcellular localization is altered in Alzheimer’s disease brain, in the Journal: (JOURNAL)
• what: The authors report that a decrease in SphK2 protein cytosolic expression correlated with the density of amyloid deposits in a cohort of post-mortem brains. Because the nuclear immunostaining of SphK2 was difficult to quantify, the analysis focused on cytoplasmic SphK2 expression to avoid experimental bias.
• how: The authors used a SphK2 antibody raised against the C-terminal sequence of SphK2 the specificity of . . .
  

   

  

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