Neurosteroid activation of gaba-a receptors: a potential treatment target for symptoms in primary biliary cholangitis?

HIGHLIGHTS

  • who: Aaron Wetten et al. from the Translational and Clinical Research Institute, Newcastle University, Newcastle-upon-Tyne, UK have published the research: Neurosteroid Activation of GABA-A Receptors: A Potential Treatment Target for Symptoms in Primary Biliary Cholangitis?, in the Journal: Canadian Journal of Gastroenterology and Hepatology of 13/06/2022
  • what: In this study, the relationship between PBC-associated cognitive symptoms and allopregnanolone was explored to examine whether this potentially modifable pathway could be a target for novel therapies.
  • future: Given the emerging data that golexanolone improves cognitive symptoms through the antagonistic . . .

     

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