Neurotoxic/neuroprotective effects of clozapine and the positive allosteric modulator of mglur2 jnj-46356479 in human neuroblastoma cell cultures

HIGHLIGHTS

  • who: Patricia Gassu00f3 and collaborators from the Department Basic Clinical Practice, University, Spain have published the paper: Neurotoxic/Neuroprotective Effects of Clozapine and the Positive Allosteric Modulator of mGluR2 JNJ-46356479 in Human Neuroblastoma Cell Cultures, in the Journal: (JOURNAL) of 13/01/2023
  • what: The authors evaluated for the first time the putative neuroprotective and antiapoptotic activity in a human neuroblastoma cell line and compared it with the effect clozapine (CLZ) as a clinical AP with the highest efficacy and with apparent utility in managing negative symptoms. Given that both PGK1 and PGAM1 codify . . .

     

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