Neutralization of hepatitis b virus with vaccine-escape mutations by hepatitis b vaccine with large-hbs antigen

HIGHLIGHTS

  • who: Ayaka Washizaki from the Monkey experiments In this study, nine rhesus macaques (3, years of age, male or female, and approximately , kg body weight) were used as a nonhuman primate model for immunization with HB vaccinesAll monkeys were supplied from colonies at the Center for the Evolutionary Origins of Human Behavior, Kyoto University. The monkeys were reared in outdoor group cages with wooded toys provided as environmental enrichment. They were fed apples, potatoes, and commercial monkey diets. They were able to access water ad libitum. They had health records from birth with yearly health checkups. We . . .

     

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