HIGHLIGHTS
SUMMARY
The pandemic spread of SARS-CoV-2 has resulted in the selection of a consistent number of variants or genetic lineages. The B.1.617.2 variant is characterized by several Spike protein mutations, including L452R and P681R, that apparently affect the immune_responses, reducing the COVID-19 vaccines` efficacy against this variant in terms of symptomatic disease. Although this vaccine was initially highly effective against COVID-19 illness and hospitalizations, changes in the coding_sequence of the Spike protein among different variants could adversely affect the vaccine-induced immune_response, making the vaccine less effective or . . .
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