Neutrophils in pancreatic cancer: potential therapeutic targets

HIGHLIGHTS

  • who: Wenkai Jiang from the Italy University Hospital in Halle, Germany have published the article: Neutrophils in pancreatic cancer: Potential therapeutic targets, in the Journal: (JOURNAL)
  • what: GM-CSF-mediated increased neutrophil infiltration is the main reason that STAT5 promotes pancreatic fibrosis and chronic pancreatitis .
  • how: The results showed that DS-8273A eliminated polymorphonuclear MDSCs (PMN-MDSCs immature neutrophils) and prolonged progression-free survival .
  • future: It is also one of the future directions to conduct joint research with related chronic diseases in cancer mechanistic studies . The authors also propose future directions . . .

     

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