HIGHLIGHTS
- who: Andr#_#x00E9 and collaborators from the Health Research Institute, Durban, South Africa, Department of Microbiology, University of Alabama at have published the research: New 2-Ethylthio-4-methylaminoquinazoline derivatives inhibiting two subunits of cytochrome bc1 in Mycobacterium tuberculosis, in the Journal: Microorganisms of January/23,/2020
- what: In this study the mode of action of potent quinazoline derivatives was investigated against tuberculosis (M. tb). Interestingly the authors demonstrate that resistance to the quinazoline derivatives as well as to other QcrB inhibitors like Q203 AX-35 and lansoprazole sulfide may emerge through a mutation . . .
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