New 5-aryl-1,3,4-thiadiazole-based anticancer agents: design, synthesis, in vitro biological evaluation and in vivo radioactive tracing studies

HIGHLIGHTS

• who: Rana M. El-Masry and collaborators from the Organic Chemistry Department, Faculty of Pharmacy, October University for Modern Sciences and have published the article: New 5-Aryl-1,3,4-Thiadiazole-Based Anticancer Agents: Design, Synthesis, In Vitro Biological Evaluation and In Vivo Radioactive Tracing Studies, in the Journal: Pharmaceuticals 2022, 1476 of /2022/
• what: A new series of 5-(4-chlorophenyl)-1,3,4-thiadiazole-based compounds featuring pyridinium (3), substituted piperazines (4a-g), benzyl piperidine (4i), and aryl aminothiazoles (5a-e) heterocycles were designed and synthesized as potential anticancer agents.
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