New antiproliferative 3-substituted oxindoles inhibiting egfr/vegfr-2 and tubulin polymerization

HIGHLIGHTS

  • who: Hend A. A. Ezelarab from the Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, u2011Mini, Minia, Egypt have published the Article: New antiproliferative 3-substituted oxindoles inhibiting EGFR/VEGFR-2 and tubulin polymerization, in the Journal: (JOURNAL)
  • what: The current research work was employed to synthesize a novel series of 3-substituted oxindole derivatives 6a-j as antiproliferative agents aiming to target multiple cellular targets concurrently.
  • how: These results showed that compound 6f had a relatively good safety profile on the HSF normal cells than 5FU. This research work was employed . . .

     

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