New c3h kitn824k/wt cancer mouse model develops late-onset malignant mammary tumors with high penetrance

HIGHLIGHTS

• who: Tanja Klein-Rodewald from the InstitutKlinikum Freiburg, Freiburg, Germany have published the research work: New C3H KitN824K/WT cancer mouse model develops late-onset malignant mammary tumors with high penetrance, in the Journal: Scientific Reports Scientific Reports

SUMMARY

Bone marrow total cell counts were similar in six months old mutant and control females, but significantly elevated compared to controls at 12 months in mutants (Fig 1h). Colony assays revealed increased proliferative activity of stem_cells from younger heterozygous mice, but decreased proliferation and elevated apoptosis rates of stem_cells from older mutants (Supplement 2 . . .

 



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