New-generation heterocyclic bis-pentamethinium salts as potential cytostatic drugs with dual il-6r and mitochondria-targeting activity

HIGHLIGHTS

• who: Veronika Talianovu00e1 et al. from the BIOCEV, First Faculty of Medicine, Charles University, , Vestec have published the research work: New-Generation Heterocyclic Bis-Pentamethinium Salts as Potential Cytostatic Drugs with Dual IL-6R and Mitochondria-Targeting Activity, in the Journal: Pharmaceutics 2022, 14, x FOR PEER REVIEW of 17/08/2022
• what: As both Bis-PMSs 5 and 6 rapidly accumulated in the mitochondria in all cell types used in this study, the authors investigated their possible effect on mitochondrial respiration by employing the Seahorse Bioanalyzer. The authors clearly showed metabolic differences, such as . . .
  

   

  

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