New in vitro interaction-parasite reduction ratio assay for early derisk in clinical development of antimalarial combinations

HIGHLIGHTS

  • who: Sebastian G. Wicha and colleagues from the Global Health Institute of Merck, Ares Trading SA, Eysins, SwitzerlandUniversity of have published the research: New In Vitro Interaction-Parasite Reduction Ratio Assay for Early Derisk in Clinical Development of Antimalarial Combinations, in the Journal: (JOURNAL) of 05/Dec/2022
  • what: The authors show how the assay allowed the authors to identify the PK/PD relationship as a function of the concentrations of drug A and drug B. The approach suggests that animal experiments can be reduced and performed in a confirmatory fashion, thus reducing the number . . .

     

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