New insights into molecular organization of human neuraminidase-1: transmembrane topology and dimerization ability

HIGHLIGHTS

• who: Pascal Maurice from the LaboratoireMoscow, Russia have published the paper: New Insights into Molecular Organization of Human Neuraminidase-1: Transmembrane Topology and Dimerization Ability, in the Journal: Scientific Reports Scientific Reports
• what: To shed light on the molecular structural details of NEU1 interaction within the membrane and its ability to dimerize in the membrane-bound state, the authors focused on the most probable TM region (TM2) 316 PVVAAGAVVTSSGIVFFS333 (NEU1/TM2) delineated based on the sequence analysis (Fig 1). The use of MD simulations throughout this study had four aims: (i) check if TM helices . . .
  

   

  

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