HIGHLIGHTS
SUMMARY
Cryptorchidism is the clinical condition in which the testes fail to descend into the scrotum, and it is considered one of the most frequent congenital malformations of the genitourinary tract, with an incidence of 1.6% to 9.0% in newborn males. The phenotypes of males with INSL3 mutations vary from bilateral undescended testes, unilateral undescended testes, and the failure of the testes to descend normally into the scrotum at birth, but with a spontaneous descent during the first year of life. The highest concentration of INSL3 in fetal life is proven between 15 . . .
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