HIGHLIGHTS
SUMMARY
Although the mitochondrial outer membrane is permeable to small_molecules due to the presence of transport proteins called porins, the inner membrane is impermeable to ions or small_molecules. Conversely, sometimes a Lineweaver-Burk plot by itself may not be enough to establish the correct mechanism of action of a ligand, and the conclusion, that an inhibitor should bind to the same binding_site of the substrate because the double reciprocal plot displays lines intersecting at the Y (ordinate) axis, could be misleading. The last reremaining predicted binding_site, facing the mitochondrial_matrix, was in correspondence maining predicted binding . . .
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