New mechanism for mesenchymal stem cell microvesicle to restore lung permeability: intracellular s1p signaling pathway independent of s1p receptor-1

HIGHLIGHTS

SUMMARY

Mesenchymal stem_cell (MSC)-based therapy for the treatment of acute lung injury is very attractive. The authors found that MSC MV increased sphingosine-1-phosphate (S1P) kinase1 mRNA levels significantly, which indicates that S1P signaling may also play a role in the restoration of endothelial permeability by MSC MV. Mesenchymal stem_cells Human BMSCs were purchased from Promocell (Promocell, C-12974, Germany, www.​promo​cell.​com). Meanwhile, as compared with LPS group, Rac1 activation in HLMVEC in both the LPS + MV and LPS + MV + W123 groups significantly increased, but no difference was found in the . . .

 



If you want to have access to all the content you need to log in!

Thanks :)

Username or Email

Password

Remember me

Lost your password?

If you don't have an account, you can create one here.