HIGHLIGHTS
SUMMARY
Comparative analysis between melanocytes and melanoma cells demonstrated that hepatoma-derived growth factor and nucleophosmin B23 present increased expression in malignant cell lines. The authors found mass spectrometry as a promising approach for the characterization of different melanoma cell lines by offering the possibility of massive analysis of proteins amounts within the cells. Depending on the cell line, the cells were seeded as follows: 104 cells of A375 and SKMEL28, 2x104 cells of MNT1 and 1.5x104 cells of Me290 and SKMEL23. Analyzing two amelanotic and three melanotic cell lines with different degree of . . .
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