New paradigms for understanding and step changes in treating active and chronic, persistent apicomplexan infections

HIGHLIGHTS

• who: Martin McPhillie from the University of Liverpool, Liverpool, UK have published the paper: New paradigms for understanding and step changes in treating active and chronic, persistent apicomplexan infections, in the Journal: Scientific Reports Scientific Reports
• what: Noting the previous work of GSK on the preclinical development of Clopidol derivatives which led to terminating studies secondary to toxicity in the rat models, as another serious deficiency62 and the incorporation of the diphenyl ether group onto the central 4-(1H)-quinolone core as reported by Riscoe et_al27, the authors focused on the central core ring system . . .
  

   

  

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