Nf-κb/p52 augments ets1 binding genome-wide to promote glioma progression

HIGHLIGHTS

• who: Nicholas Sim from the SchoolTechnological University have published the research: NF-u03baB/p52 augments ETS1 binding genome-wide to promote glioma progression, in the Journal: (JOURNAL)
• what: The authors show that p52 activation directly regulates ETS1 expression through p52 binding at its promoter. This analysis showed that both groups of DEGs shared enrichment of similar biological processes relating to cell proliferation and JAK-STAT pathway activation. The authors report a similar signature whereby TWEAK-induced p52 activity resulted in the increased enrichment of oncogenic motifs such as various ETS factors KAISO and ZEB1 at . . .
  

   

  

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