Nh3/nh4+ allosterically activates slc4a11 by causing an acidic shift in the intracellular pk that governs h+(oh−) conductance

HIGHLIGHTS

• What: The authors focus on the robust and repeatable Na+independent H + transport action of SLC4A11, an action that is stimulated by increases in pHi, extracellular pH (pHe), and NH 4Cl (Zhang et_al, 2015; Myers et_al, 2016; Kao et_al, 2020; Quade et_al, 2020) and which is also disrupted by disease-causing mutations (Kao et_al, 2015; Quade et_al, 2022). The authors show that, if the authors consider these data as being behavior of the protein from that of the system, the best that such calculations may achieve is a description of the permeability of the system (i.e . . .
  

   

  

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