Niche derived netrin-1 regulates hematopoietic stem cell dormancy via its receptor neogenin-1

HIGHLIGHTS

• who: Simon Renders from the of Stem Cells and Cancer, German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance, Heidelberg, GermanyUniversity Hospital have published the research work: Niche derived netrin-1 regulates hematopoietic stem cell dormancy via its receptor neogenin-1, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
• what: The authors report gene sets associated with nuclear factor-κB (NF-κB) signalling, as well as signalling of the NEO1 ligand netrin-1 (Ntn1) to be depleted in Neo1-mutant HSCs, suggesting that these signalling pathways may be downstream of NEO1 activation (Fig 4f). The studies . . .
  

   

  

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