Nirmatrelvir-resistant sars-cov-2 variants with high fitness in an infectious cell culture system

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  • who: Zhou and colleagues from the wnloaded from https://wwwscience.org at Technical University of Denmark on January, have published the Article: Nirmatrelvir-resistant SARS-CoV-2 variants with high fitness in an infectious cell culture system, in the Journal: (JOURNAL) of 21/Dec/2022
  • what: To facilitate population monitoring for potentially emerging nirmatrelvir-resistant SARS-CoV-2_variants, the authors aimed to identify nirmatrelvir resistance-associated substitutions. The authors report the identification of substitutions in SARS-CoV-2 Mpro conferring substantial and likely clinically relevant resistance to the first-in-class oral protease inhibitor nirmatrelvir . . .

     

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